Translational & Clinical Research
Doctorate of Philosophy (PhD) Thesis 
Emergence and Margins in Head and Neck Cancer: A new understanding

Cancer has been widely accepted as a genetic disease. This thesis challenges this assumption and proposes that cancer be considered as an emergent complex system. A new framework for carcinogenesis and cancer progression is presented. This framework is applied to identify biological markers with the potential to predict recurrence in oral cancer. A simple dual staining technique is developed to test the identified biomarkers. The results support the use of these biomarkers as a predictor of recurrence over and above traditionally measured cancer clearance.

PhD Thesis Emergence & Margins Dr E Sigs
Research Grants & Clinical Trials

October 2020

Advancing Women in Healthcare Leadership

 

Grant:

NHMRC Partnership Projects


Funding:

Project Grant AUD 752,694


Principal Investigator:

Professor Helena Teede

Professor Helen Skouteris

A/Professor Jacqueline Boyd

Professor Kathleen Riach

Professor Caroline Homer

Professor Ian Mcloughlin

Professor Julian Smith

Professor Nickolajs Zeps 


Principle Institution:

Monash University (VIC, Australia)

(continued.....)

October 2019

Nyxoah BETTER SLEEP Trial

 

Trial:

Nyxoah BETTER SLEEP Trial

Trial Summary:

The BETTER SLEEP trial was designed to assess the long-term safety and performance of the Genio® bilateral hypoglossal nerve stimulation system (the “Genio® system”) in 42 adult OSA patients with and without Complete Concentric Collapse (CCC) of the soft palate.

 

Role:

Primary Investigator and implant 

surgeon for Monash University Site

Primary Investigators:


Principle Institution:

Monash University (VIC, Australia)

April 2015

Blood serum micro RNA biomarkers for detection of oropharyngeal cancer

 

Grant:

Garnett Passe and Rodney Williams Memorial Foundation Conjoint Grant


Funding:

Project Grant AUD 371,375


Principal Investigator:

Dr. Eng Ooi,

Dr. Damian Hussey


Principle Institution:

Flinders Medical Centre (SA, Australia)


Co-investigators:

Dr. Elizabeth Sigston


Secondary Institutions:

Monash Health (VIC, Australia)

October 2020 (..continued)

Advancing Women in Healthcare Leadership

(continued)

Associate-investigators:

A/Professor Elizabeth Sigston

Professor Lee Boyd

Dr Anju Joham

Professor Bernard Crump

Dr Anjali Dhulia

Ms Ann Maree Keenan

Professor Jacinta Elston

Dr Christine Lai

Ms Tanya Duffy

Dr Rosalie Grivell


Major Partners:

Monash Health (VIC, Australia)

Epworth

Impact Partners:

Cabrini Health

Australian College of Nursing

AMA

Eastern Health

December 2018

3D Printing for Reconstruction in Head & Neck Cancer

 

Grant:

Garnett Passe and Rodney Williams Memorial Foundation Conjoint Grant


Funding:

Project Grant AUD 374,500


Principal Investigator:

Dr. Elizabeth Sigston,

Dr. Andrey Molotnikov


Principle Institution:

Monash University (VIC, Australia)


Co-investigators:

Professor Laurence Meagher,

Professor Chris Davies,

Mr Felix Sim


Secondary Institutions:

Monash Health (VIC, Australia)

March 2011

The Role of Laminin γ2 in oral tongue squamous cell carcinoma as a prognostic marker, Laminin γ2 Serum levels as a measure of effective treatment of oral and oropharyngeal squamous cell carcinoma

Grant:

Victorian Cancer Agency Fellowship Grant*


Funding:

Fellowship and Project Grant AUD 300,000


Principal Investigator:

Dr. Elizabeth Sigston


Principle Institution:

Monash Health (VIC, Australia)


Co-investigators:

Dr. Neil Watkins,

Dr. Ben Solomon


Secondary Institutions:

Monash Institute of Medical Research (MIMR), Monash University (VIC, Australia)

Peter MacCallum Cancer Centre (VIC, Australia)

*Grant declined due to support issues at Monash Health & personal circumstances

January 2020

Validation of p63/vimentin co-staining to predict recurrence in HNSCC

 

Grant:

Royal Australasian College of Surgeons Small Project Grant


Funding:

Project Grant AUD 10,000


Principal Investigator:

Dr. Elizabeth Sigston,


Principle Institution:

Monash University (VIC, Australia)


Co-investigators:

Megan Blom


Secondary Institutions:

Monash Health (VIC, Australia)

January 2016

3D Printing for Reconstruction in Head & Neck Cancer

 

Grant:

MIME Seed Funding: Monash Institute Of Medical Engineering (MIME)


Funding:

Project Grant AUD 50000

PhD Student Scholarship AUD 90000 (30000 x 3 years)


Principal Investigator:

Dr. Elizabeth Sigston,

Dr. Andrey Molotnikov


Principle Institution:

Monash University


Co-investigators:

Professor George Simon,

Professor Nick Birbilis,

Professor Xinhua Wu,

Professor Chris Davies


Secondary Institutions:

Monash Health (VIC, Australia)

April 2007

Emergence and Margins in Head and Neck Cancer: An Emergence Framework for Carcinogenesis and its Application in Translational Research

 

Grant:

Garnett Passe and Rodney Williams Memorial Foundation Project Grant


Funding:

Project Grant AUD 258,309


Principal Investigator:

Dr. Elizabeth Sigston,


Principle Institution:

Department of Molecular and Translational Sciences, Monash University (VIC, Australia)


Co-investigators:

Professor Bryan Williams


Secondary Institutions:

Hudson Institute of Medical Research, Monash University (VIC, Australia)

Department of Surgery, School

of Clinical Sciences at Monash

Health, Monash University (VIC, Australia)

Monash Health (VIC, Australia)

Publications

Elizabeth Sigston, Erwan de Mones, Emmanuel Babin, Stéphane Hans, Dana M Hartl, Philippe Clement, Daniel F Brasnu: Early-Stage Glottic Cancer: Oncological Results and Margins in Laser Cordectomy. Archives of Otolaryngology - Head and Neck Surgery 03/2006; 132(2)., DOI:10.1001/archotol.132.2.147

Citations: 140

E Babin, E Sigston, M Hitier, D Dehesdin, J P Marie, O Choussy: Quality of life in head and neck cancers patients: Predictive factors, functional and psychosocial outcome. Eur Arch Otorhinolaryngol. 2008 Mar;265(3):265-70. DOI:10.1007/s00405-007-0561-0

Citations: 107

Annette M Lim, Hongdo Do, Richard J Young, Stephen Q Wong, Christopher Angel, Marnie Collins, Elena A Takano, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Stephen B Fox, Danny Rischin, Alexander Dobrovic, Benjamin Solomon: Differential mechanisms of CDKN2A (p16) alteration in oral tongue squamous cell carcinomas and correlation with patient outcome. International Journal of Cancer 08/2014; 135(4). Ci DOI:10.1002/ijc.28727

Citations: 54

Ali A Arabi Mianroodi, Elizabeth A Sigston, Neil A Vallance: Frozen section for parotid surgery: Should it become routine?. ANZ Journal of Surgery 09/2006; 76(8)., DOI:10.1111/j.1445-2197.2006.03844.x
 

Citations: 43

Rebecca S M Lim, Shakher Ramdave, Paul Beech, Baki Billah, Md Nazmul Karim, Julian A Smith, Adnan Safdar, Elizabeth Sigston: Utility of SUVmax on F-FDG PET in detecting cervical nodal metastases. Cancer imaging : the official publication of the International Cancer Imaging Society 11/2016; 16(1)., DOI:10.1186/s40644-016-0095-z

Citations: 12

R S Lim, L Evans, A P George, N de Alwis, P Stimpson, S Merriel, C E B Giddings, B Billah, J A Smith, A Safdar, E Sigston: Do demographics and tumour-related factors affect nodal yield at neck dissection? A retrospective cohort study. The Journal of Laryngology & Otology 10/2016; DOI:10.1017/S0022215116009208

Citations: 2

Elizabeth A W Sigston, Anthony Longano, Aneta T  Strzelecki, Bryan R G Williams: Surgical margins in head and neck squamous cell carcinoma: Effect of heat artifact on immunohistochemistry as a future tool for assessment. Head & Neck 04/2016; DOI:10.1002/hed.24450

Citations: 1

Annette M Lim, Ida Lm Candiloro, Nicholas Wong, Marnie Collins, Hongdo Do, Elena A Takano, Christopher Angel, Richard J Young, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Danny Rischin, Benjamin Solomon, Alexander Dobrovic: Quantitative methodology is critical for assessing DNA methylation and impacts on correlation with patient outcome. Clin Epigenetics 12/2014; 6(1)., DOI:10.1186/1868-7083-6-22 

Citations: 19

Rebecca Sin Mei Lim, Sam Flatman, Elizabeth Sigston, Anthony Longano: Lipoblastoma: An interesting differential of paediatric lipoma. ANZ Journal of Surgery 10/2013; 84(5)., DOI:10.1111/ans.12238

Citations: 6

Annette M Lim, Hongdo Do, Richard J Young, Stephen Q Wong, Christopher Angel, Marnie Collins, Elena A Takano, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Stephen B Fox, Danny Rischin, Alexander Dobrovic, Benjamin Solomon: Characterization of the differential mechanisms of CDKN2A (p16) inactivation in oral tongue squamous cell carcinomas and correlation with patient outcome. Cancer Research 04/2013; 73(8) (Supplement), DOI: 10.1158/1538-7445.AM2013-4693

Citations: 1

Richard J Young, Annette M Lim, Christopher Angel, Marnie Collins, Siddhartha Deb, June Corry, David Wiesenfeld, Stephen Kleid, Elizabeth Sigston, Bernard Lyons, Prudence A Russell, Gavin Wright, Grant A McArthur, Stephen B Fox, Danny Rischin, Benjamin Solomon: Frequency of Fibroblast Growth Factor Receptor 1 gene amplification in oral tongue squamous cell carcinomas and associations with clinical features and patient outcome. Oral Oncology 02/2013; 49(6)., DOI:10.1016/j.oraloncology.2013.01.006

Citations: 33

Truong An Pham, Yi Zhao, Elizabeth Sigston: Schwannoma of the Palatine Tonsil: A Rare Entity in an Eight Year Old Girl. 01/2013; 02(02)., DOI:10.4172/2324-9110.1000107

Citations: 1

Truong An Pham, Ryan De Freitas, Elizabeth Sigston, Neil Vallance: Factors leading to the use of alternate treatment modalities following transoral laser excision of T1 and T2 glottic squamous cell carcinoma. ANZ Journal of Surgery 08/2012; 82(10)., DOI:10.1111/j.1445-2197.2012.06138.x

Citations: 12

Mateya E Trinkaus, Andrew Coleman, Ieta D'Costa, Elizabeth Sigston, Danny Rischin: Recurrent intestinal type sinonasal adenocarcinoma treated with FOLFOX6 chemotherapy: Case report and review of literature. International Journal of Case Reports and Images 2012;3(8):17–20. DOI:10.5348/ijcri-2012-08-158-CR-5

Citations: 1

Ronald Chin, Phoebe Roche, Elizabeth Sigston, Neil Valance: Malignant otitis externa: An Australian case series. The surgeon: journal of the Royal Colleges of Surgeons of Edinburgh and Ireland 10/2011; 10(5)., DOI:10.1016/j.surge.2011.09.004

Citations: 17

Jason A Roth, Elizabeth Sigston, Neil Vallance: Endoscopic stapling of pharyngeal pouch: A 10-year review of single versus multiple staple rows. Otolaryngology Head and Neck Surgery 02/2009; 140(2)., DOI:10.1016/j.otohns.2008.10.035

Citations: 19

Philippe Clément, Stéphane Hans, Erwan de M: Dilatation for Assisted Ventilation‐Induced Laryngotracheal Stenosis. The Laryngoscope ones, Elizabeth Sigston, Ollivier Laccourreye, Daniel Brasnu: Dilatation for Assisted Ventilation‐Induced Laryngotracheal Stenosis. The Laryngoscope 10/2005; 115(9)., DOI:10.1097/01.mlg.0000172040.02154.00

Citations: 28

E Babin, E Sigston, J-Y Bigeon, M-A Doppia, E Edy: How we do it: management of tracheobronchial foreign bodies in children. Clinical Otolaryngology 01/2005; 29(6)., DOI:10.1111/j.1365-2273.2004.00921.x115(9)., DOI:10.1097/01.mlg.0000172040.02154.00

Citations: 22

Elizabeth A.W. Sigston, Claire E Iseli, Tim A Iseli: Concha bullosa: Reducing middle meatal adhesions by preserving the lateral mucosa as a posterior pedicle flap. The Journal of Laryngology & Otology 11/2004; 118(10)., DOI:10.1258/0022215042450814

Citations: 18

Michael P Colreavy, Elizabeth Sigston, Peter D Lacy, Gnaneswary S Balasubramaniam, Bernard M Lyons: Post-nasal space oncocytoma: A different approach to a rare tumour. The Journal of Laryngology & Otology 02/2001; 115(1)., DOI:10.1258/0022215011906812

Citations: 9